Dr. Lock is investigating mechanisms of glucocorticoid resistance in pediatric acute lymphoblastic leukemia (ALL) and tests potential new treatments for fast-tracking into early phase clinical trials.

Dr. Lock is Professor of Medicine at UNSW Sydney, Head of the Leukaemia Biology Group and the Blood Cancers Theme at Children’s Cancer Institute and an international leader in preclinical drug testing in acute leukemia. His work has led to the identification of novel mechanisms of glucocorticoid resistance in pediatric ALL and to the prioritization of several new agents into clinical trials aimed at improving the treatment of acute leukemia. Dr. Lock has been a Principal Investigator in the NCI-funded pediatric preclinical testing program since 2005 and carries out all of the leukemia testing for the program. He also provides a leadership role in the Australian national precision medicine clinical trial (PRISM) to utilize preclinical drug testing to assist in patient treatment decisions.