My clinical and research interest is to develop therapies that enhance the immune system to fight blood cancer. In my laboratory, we have developed CA T Cells to treat aggressive blood cancer and we have taken one already from the research lab to the clinic. This was CD4CAR. It is designed to treat T cell leukemia and lymphoma. We have treated three patients so far and results were very promising. CD4, the target for this CAR is expressed on CMML nd we are not only planning to try this CAR in CMML, but we will be studying mechanisms of response and resistance to this treatment as we go, and also improving on the structure of this CAR to be more effective with the goal of curing CMML.